How do we know if a mouse has tinnitus?
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This question, which may have occurred to you to wonder, highlights a potential problem with this study. Since tinnitus is an ever-present phenomenon, some in the research community — including the authors of this study — have embraced “gap detection” as a means of testing for the presence of the condition in animals. The idea of gap testing is that, since tinnitus is constant, an animal wouldn’t be able to hear gaps between a series of audio tones being played. Gap detection is tested by monitoring an animal’s acoustic startle reflex to each new tone as it sounds — in theory, an animal with tinnitus won’t notice or react to each new tone. However, it’s worth noting that the value of gap detection testing for tinnitus is controversial.
All that having been said, there are a number of anti-inflammatory medications, and as used in the research, genetic means of controlling the presence of TNF-α. If the authors’ findings are eventually confirmed to be valid in human subjects, there may be hope for tinnitus sufferers at last.