There’s no cure for psoriasis, and even a medical treatment plan that helps to manage the disease and minimize flares isn’t guaranteed to alleviate all symptoms. If you’d like to try some home remedies for psoriasis, talk to your doctor — and be aware that some herbal remedies can cause dangerous interactions with medications, and may be harmful if you are pregnant or breastfeeding, have a mood disorder or have another pre-existing condition such as diabetes or high blood pressure.
I always look forward to autumn. Fall is all about breaking out the cozy fabrics like cashmere and pashmina and showing off those new ankle boots. It’s probably my favorite season to dress for because I’m not stressing out about my flare-ups as much, and I can be comfortable in the skin that I’m in while looking stylish.
Here are my top 7 fall fashion tips for ladies with psoriasis
1. Invest in a good denim jacket.
Who knew an ’80s trend would make a comeback?! You can never go wrong with a classic denim jacket. My flare-ups don’t stand a chance in getting me down when I have my jean jacket on. It’s perfect to pair with light layers, tights and even a cute dress with boots.
2. Layer up with light-weight fabrics.
Stick with light-weight fabrics like pashmina, cashmere, rayon and soft knit. When the weather drops in degrees, you can feel comfortable knowing that you’re still allowing your skin to breathe.
3. All about the leggings.
These are all the rage right now, so have fun with it! And who wouldn’t feel good about themselves with the fun patterns and bright colors you have to choose from? Layer those leggings with tunics, long sweaters and vests, then you’re good to go!
4. Cowl necks are the new turtlenecks.
If where you live winter means 60 degrees and flip flops, opt for large billow-y cowl necks. The great thing about these is that you can pair it over a lightweight long sleeve shirt, jeans and ankle boots and still feel fashion-forward and cozy for the cooler weather. If temps start to dip, throw on your denim or leather jacket, and you’re set for the night.
5. Boots for days.
Ankle, knee high, thigh high, short heel, high heel, fringe… the options are endless! Even when I’m having a flare, I’ll put on my favorite pair of boots and instantly feel better. So this season, put away the black boots and grab a funkier pair. A little change never hurt anyone!
6. Mix textures.
Fall is probably one of the only seasons you can get away with mixing textures like pashmina and velvet, silk and cashmere. So have some fun with fabrics and textures, and your flare-ups will never know what hit them. Did I mention how chic you’ll feel? Who doesn’t need that in the winter?
7. Don’t forget to accessorize.
Fall is the perfect weather for all those scarves and hats you’ve been holding onto. Scarves can make the perfect statement to any wardrobe. When I’m having a flare-up, I break out any of my scarves and it changes my whole day around. The winter can be particularly harsh on scalp psoriasis. If that’s your case, don a wide-brimmed hat or classic fedora, and you’ll be the life of the party.
More than 8 million people in the United States are affected by psoriasis, a chronic skin disease associated with overactive inflammatory and immune responses.1,2 Approximately 80% to 90% of individuals with psoriasis have plaque psoriasis, the most common form of the disease, which is characterized by thick, raised patches (plaques) that can present anywhere on the skin, but most often appear on the knees, elbows, lower back, and scalp.3,4 In addition, plaque psoriasis is often accompanied by pruritus (severe itching), pain, and, in some cases, bleeding of psoriatic patches.4
Plaque psoriasis imposes a substantial burden on the patient’s physical, social, and psychological well-being.5 Overall, 60% of patients report that psoriasis is very problematic in their everyday life; moderate-to-severe disease inflicts the greatest negative impact on quality of life.1 Furthermore, as many as 35% of people with psoriasis will eventually have psoriatic arthritis.5 In addition, individuals with psoriasis are at an increased risk for depression, cardiovascular disease, type 2 diabetes, kidney disease, metabolic syndrome, and eye disorders.6
Patients with plaque psoriasis may receive treatment with topical agents, phototherapy, conventional systemic therapies (ie, cyclosporine, methotrexate, retinoids) and other systemic therapies, including an oral phosphodiesterase-4 inhibitor, biologic therapies (ie, tumor necrosis factor inhibitors, interleukin [IL]-17 antagonists, IL-23 antagonists, and an IL-12/IL-23 antagonist), and biosimilar agents.7-9
RISANKIZUMAB-RZAA FDA APPROVED FOR PLAQUE PSORIASIS
On April 23, 2019, risankizumab-rzaa (Skyrizi; AbbVie), an IL-23 antagonist, was approved by the US Food and Drug Administration (FDA) for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.10
Commenting on the approval of risankizumab, Kenneth B. Gordon, MD, Professor and Chair of Dermatology, Medical College of Wisconsin, and chief investigator for the UltIMMa-1 clinical trial, stated, “The complex nature of psoriasis and the variability or loss of treatment response over time can prevent some patients from achieving their treatment goals.”10 Dr Gordon added, “In clinical trials, risankizumab demonstrated high levels of skin clearance that persisted through one year. I’m pleased the dermatology community now has a new option that can help patients achieve and maintain a high level of treatment response.”10
MECHANISM OF ACTION
IL-23 is a naturally occurring cytokine that plays a role in the inflammatory and immune responses that are implicated in the pathogenesis of psoriasis.11
Risankizumab, a humanized immunoglobulin G1 monoclonal antibody, selectively binds to the p19 subunit of human IL-23 cytokine and blocks its interaction with the IL-23 receptor, thereby inhibiting the release of proinflammatory cytokines and chemokines.11
DOSING AND ADMINISTRATION
Risankizumab is available for injection as a 75-mg/0.83-mL solution in a single-dose prefilled syringe.11
The recommended dose of risankizumab is 150 mg (two 75-mg injections) administered by subcutaneous injection at week 0, week 4, and every 12 weeks thereafter. Patients should be evaluated for tuberculosis infection before initiating treatment with risankizumab.11
PIVOTAL CLINICAL TRIALS
UltIMMa-1 and UltIMMa-2
The efficacy and safety of risankizumab were evaluated in 2 phase 3 clinical trials, UltIMMa-1 and UltIMMa-2, double-blind, randomized, placebo-controlled studies that included 997 patients (mean age, 48 years in UltIMMa-1 and 47 years in UltIMMa-2) with moderate-to-severe plaque psoriasis.12
Patients in both studies received treatment at weeks 0, 4, and every 12 weeks thereafter. In both studies, a significantly greater proportion of patients receiving risankizumab achieved a 90% improvement in Psoriasis Area and Severity Index (PASI; PASI 90) and static Physician’s Global Assessment (sPGA) score of 0 or 1 at week 16 compared with patients receiving placebo (Table).11,12
The treatment response with risankizumab was sustained at 1 year.11,12 In the UltIMMa-1 trial, 58% of patients who received treatment with risankizumab achieved an sPGA score of 0, 82% achieved a PASI 90, and 56% achieved a PASI 100 at week 52. In the UltIMMa-2 trial, 60% of the patients who received treatment with risankizumab achieved an sPGA score of 0, 81% achieved a PASI 90, and 60% achieved a PASI 100 at week 52.12
Among patients in UltIMMa-1 and UltIMMa-2 who received risankizumab and achieved a PASI 100 at week 16, 80% who continued with risankizumab treatment maintained a PASI 100 at week 52; of those who achieved a PASI 90 at week 16, 88% of patients maintained a PASI 90 at week 52.12
Psoriasis is a chronic skin condition marked by itchiness, redness, dryness, and often a flaky and scaly appearance. This disease doesn’t have a cure and develops when an overactive immune system causes faster than normal cell growth. For people living with psoriasis, new skin cells surface every three to four days (as opposed to every 28 to 30 days for everyone else).
Psoriasis can be emotional and stressful for sufferers, especially when the disease is widespread and covers large areas of the body. If you know someone living with it, your support and encouragement can make a world of difference. If you don’t know much about this condition, you may wonder how to offer support. Although your loved ones will appreciate any effort you make, here’s a look at six specific ways to help those living with psoriasis.
1. Learn about the disease
Psoriasis is often misunderstood. If you don’t know much about the condition, you could make inaccurate assumptions or comments. Misguided advice and insensitive remarks are frustrating for those living with psoriasis, and can make them feel worse about their condition. Maybe you think psoriasis is contagious, so you keep your distance to avoid contracting the illness. By researching the disease, however, you’ll learn that it’s an autoimmune disease that can’t be passed from person to person.
The more you understand, the easier it will be to offer practical assistance and help sufferers cope with flare-ups. People living with psoriasis need a strong support network. They may not want to discuss their disease 24/7, but may welcome your questions when asked in an appropriate setting. Still, don’t bombard them with questions. It’s your responsibility to do your own research.
2. Don’t stare at their skin
Psoriasis flare-ups vary from person to person, and the severity of the disease can range from mild to severe. Some people living with psoriasis only develop symptoms on areas of the body easily hidden from sight. Therefore, the disease may not have an overt social or emotional impact on them. Others have a more severe case, and psoriasis may cover a greater portion of their body.
To support someone living with this disease, make a conscious effort not to stare at their skin. The more you do, the more distressing the disease becomes for them, especially if they’re already self-conscious. Put yourself in their shoes. How would you feel if all eyes were on your skin during a flare-up?
Educate your children about this skin disease too. Talk about the condition and explain that it’s not contagious. This is important if your child has a friend or relative with the disease. Also, teach children not to stare or make comments about dry patches or scaly skin.
3. Encourage outdoor activity
Sunlight, in limited doses, can soothe psoriasis symptoms. For that matter, spending time outdoors can help someone living with this disease. Rather than sit in the house, encourage outdoor activity on a sunny day. Suggest going for a walk together, a hike, or a bike ride. Outdoor activity not only provides a healthy dose of natural vitamin D, it can take someone’s mind off the disease, strengthen their immune system, and boost their energy level.
Psoriasis is a complex disease that manifests itself in different ways in different people. Here, we answer common questions and concerns.